Growth is central to life, shaping physiology, ecology, and evolution. In this talk, I discuss our efforts to elucidate the causes and consequences of bacterial growth across scales. Starting from resource allocation models and the molecular and energetic demands of protein synthesis, I first introduce how bacterial cells adjust their…
Groups of cells of all kinds work together as part of multicellular behaviors ranging from collective migration to development. These behaviors are coordinated at the level of single cells, where information about other cells and the environment are encoded in intracellular signaling dynamics that then drive cellular-level behaviors. We face…
Pseudomonas aeruginosa is an opportunistic bacterial pathogen. Most P. aeruginosa isolates are infected by a filamentous virus (phage) called Pf. At sites of infection, filamentous Pf virions accumulate where they increase mucus viscosity, promote bacterial colonization, and directly stimulate innate anti-viral immune…
Danqi Chen Princeton University
Irina Rish Université de Montréal and Mila-Quebec AI Institute
Alexander Rush Cornell…
From precise microbial genomics to precision medicine
Ami S Bhatt
Stanford University
More than 1,000 species of bacteria, archaea, viruses and fungi live in the human gut. Far from being passive passengers, these organisms strongly interact with one another and…
Many of the physical processes in a cell consume energy, but we are only beginning to understand how these costs have influenced the course of evolution. Biology is strewn with counter-intuitively complex mechanisms whose evolutionary predecessors must have consumed significant energy resources without any clear fitness benefit. So…
Circadian clocks regulate the timing of various behavioral and physiological activities in most organisms on a 24-hr scale such that they are phased appropriately to external, cyclic changes in the environment. The clock neuronal network in Drosophila melanogaster is comprised of ~150 neurons distributed bilaterally in the brain,…