Zaida Luthey-Schulten: Modeling the minimal cell: Integration of experiments, theory, and simulations

Mon, Sep 23, 2019, 12:00 pm
Location: 
Joseph Henry Room Jadwin Hall
Speaker(s): 
Sponsor(s): 
CPBF an NSF PFC

JCVI-syn3A, a robust minimal cell with a 543 kbp genome and 493 genes, provides a versatile platform to study the principles of life (Breuer et al. eLife 2019). Using the vast amount of experimental information available on its precursor, Mycoplasma mycoides capri, we assembled a near-complete essential metabolic network with 98% of enzymatic reactions supported by annotation or experiment. This coherent model of the minimal metabolism along with the maps of all its protein-coding genes and proteomics data point toward specific open questions regarding the minimal genome, which still contains many genes of generic or completely unclear function. The identification of 30 essential genes with unclear function will motivate the search for new biological mechanisms beyond metabolism. Finally, stochastic dynamics of the combined genetic information processes of DNA replication, transcription, translation and ribosome biogenesis clarifies quantitatively demands on the metabolic network over the twohour cell cycle.

Andrew York: A bolt-on single-objective light-sheet design with uncompromised numerical aperture

Mon, Feb 24, 2020, 12:00 pm

Spinning disk confocal modules are “core facility friendly”; they insert conveniently between a commercial microscope base and camera, improve...

Location: Joseph Henry Room Jadwin Hall

Andreas Gahlman: TBD

Mon, Mar 9, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Andreas Gahlmann: Visualizing Bacterial Physiology at High Resolution using Single-Molecule Tracking and Lattice-Light Sheet Microscopy

Mon, Mar 9, 2020, 12:00 pm

Our lab develops new imaging approaches for visualizing bacterial physiology in relevant contexts: We use live-cell single-molecule localization...

Location: Joseph Henry Room Jadwin Hall

CPBF undergraduate outreach at CUNY

Fri, Mar 13, 2020, 1:30 pm to 4:00 pm
Location: Science Center (4102) at The Graduate Center. 365 Fifth Avenue, New York

Allan Drummond: Evolution of low-complexity protein regions implicated in biomolecular condensation

Na Ji: Imaging the brain at high spatiotemporal resolution

Mon, Mar 23, 2020, 12:00 pm

To understand computation in the brain, one needs to understand the input-output relationships for neural circuits and the anatomical and...

Location: Joseph Henry Room Jadwin Hall

Stefano Allesina: TBD

Mon, Mar 30, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Justin Kinney: Massively parallel assays, machine learning, and the biophysics of gene regulation

Mon, Apr 6, 2020, 12:00 pm

Gene expression in all organisms is controlled by short DNA and RNA sequences called cis-regulatory elements (CREs).

Location: Joseph Henry Room Jadwin Hall

David Van Valen: Deep learning for single cell biology

Mon, Apr 13, 2020, 12:00 pm

The study of living systems is challenging because of their high dimensionality, spatial and temporal heterogeneity, and high degree of...

Location: Joseph Henry Room Jadwin Hall

Problems in neural and cognitive computation

Fri, Apr 17, 2020, 10:00 am

Using food-caching birds to study the neuroscience of episodic memory
Dmitriy Aronov, Columbia University

Location: Segal Theater at The Graduate Center. 365 Fifth Avenue, New York

Seppe Kuehn: TBD

Mon, Apr 20, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Gurol Suel: TBD

Mon, Apr 27, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall