Sven van Teeffelen: Control of cell volume in rod-shaped bacteria

Mon, Feb 3, 2020, 12:00 pm
Location: 
Joseph Henry Room Jadwin Hall
Speaker(s): 
Sponsor(s): 
CPBF an NSF PFC

Bacteria exhibit a high degree of intracellular macromolecular crowding. To control the level of crowding cells must increase their volumes in response to the accumulation of biomass during growth. This coordination is fundamentally not understood in any cell type. Using rod-shaped bacteria Escherichia coli and Bacillus subtilis as a model organism, we found that cells control volume indirectly, by robustly increasing cell-surface area rather than volume in proportion to biomass. Therefore, dry-mass density changes with cell shape, both during the cell cycle and during nutrient shifts, in direct proportion to the surface-to-volume ratio.

The major contribution to mass-density variations during nutrient shifts comes from changes of cell width. We found that these variations are likely driven mechanically, through nutrient-dependent changes of Turgor pressure. Thus, we identified cell dimensions and a new, slowly varying surface-to-mass coupling constant as the sole independent variables responsible for the coordination of volume with mass growth.

Through a range of perturbations and the analysis of single-cell correlations we elucidate potential mechanisms underlying surface-to-mass coupling and adaptation. Together, our experiments reveal important regulatory relationships underlying crowding and envelope homeostasis.

Dmitry Rinberg: Cracking the olfactory code using behavior

Mon, Jan 27, 2020, 12:00 pm

Two of the most fundamental questions of sensory neuroscience are: 1) how is stimulus information represented by neuronal activity?

Location: Joseph Henry Room Jadwin Hall

Sven van Teeffelen: Control of cell volume in rod-shaped bacteria

Mon, Feb 3, 2020, 12:00 pm

Bacteria exhibit a high degree of intracellular macromolecular crowding.

Location: Joseph Henry Room Jadwin Hall

Elizabeth Jerison: Dynamics of adaptive immunity in zebrafish

Mon, Feb 10, 2020, 12:00 pm

The immune responses that defend us against pathogens are driven by stochastic processes amongst populations of cells.

Location: Joseph Henry Room Jadwin Hall

Stephanie Palmer: How behavioral and evolutionary constraints sculpt early visual processing

Mon, Feb 17, 2020, 12:00 pm

While efficient coding has been a successful organizational principle in visual neuroscience, to make a more general theory behavioral,...

Location: Joseph Henry Room Jadwin Hall

Information flow in bacterial communities

Fri, Feb 21, 2020, 9:30 am

Location: The Graduate Center, Room 4102. 365 Fifth Avenue, 365 Fifth Avenue, New York

Andrew York: TBD

Mon, Feb 24, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Andreas Gahlman: TBD

Mon, Mar 9, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Andreas Gahlmann: TBD

Mon, Mar 9, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

CPBF undergraduate outreach at CUNY

Fri, Mar 13, 2020, 1:30 pm to 4:00 pm
Location: Science Center (4102) at The Graduate Center. 365 Fifth Avenue, New York

Allan Drummond: TBD

Mon, Mar 16, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Na Ji: Imaging the brain at high spatiotemporal resolution

Mon, Mar 23, 2020, 12:00 pm

To understand computation in the brain, one needs to understand the input-output relationships for neural circuits and the anatomical and...

Location: Joseph Henry Room Jadwin Hall

Stefano Allesina: TBD

Mon, Mar 30, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall