University of California San Diego
We have been working to measure and understand how ion fluxes and ionic interactions regulate fundamental biological processes, and in particular promote stress tolerance in bacteria. I will present our recent work that builds on our discovery of action potentials generated within bacterial biofilms. Specifically, we showed that bacteria use potassium ion channels to orchestrate various population-level stress responses. For this talk, I will present how individual bacteria utilize magnesium flux to protect their ribosomes against antibiotics. I will propose that in contrast to the common assumption of ion homeostasis, bacteria favor a dynamic cytoplasmic “metallome” to regulate various aspects of cell physiology.
CPBF an NSF PFC