Elizabeth Jerison: Dynamics of adaptive immunity in zebrafish

Mon, Feb 10, 2020, 12:00 pm
Location: 
Joseph Henry Room Jadwin Hall
Speaker(s): 
Sponsor(s): 
CPBF an NSF PFC

The immune responses that defend us against pathogens are driven by stochastic processes amongst populations of cells. Enormous progress in immunology over the last few decades has identified most of the components of this complex system, including the cell types and the molecules used for communication. But understanding how the dynamics of the system emerge from these components remains a major challenge. The presence of large numbers of cells following random migration, interaction, birth, and death rules suggests we take a statistical physics approach. The major hurdle to this approach is the difficulty of observing these processes in their native context at system scales. I will describe recent progress in developing a zebrafish and light-sheet microscopy system to address this gap, focused on the dynamics of adaptive immunity. As an example of this approach, I will discuss our recent observations of naive T cells in the live zebrafish, and describe how T cell motility forms a behavioral manifold that generates a broad range of length scales of exploration across the population. I will conclude by briefly discussing new opportunities opened by this system in physics and immunology.

Dmitry Rinberg: Cracking the olfactory code using behavior

Mon, Jan 27, 2020, 12:00 pm

Two of the most fundamental questions of sensory neuroscience are: 1) how is stimulus information represented by neuronal activity?

Location: Joseph Henry Room Jadwin Hall

Sven van Teeffelen: Control of cell volume in rod-shaped bacteria

Mon, Feb 3, 2020, 12:00 pm

Bacteria exhibit a high degree of intracellular macromolecular crowding.

Location: Joseph Henry Room Jadwin Hall

Elizabeth Jerison: Dynamics of adaptive immunity in zebrafish

Mon, Feb 10, 2020, 12:00 pm

The immune responses that defend us against pathogens are driven by stochastic processes amongst populations of cells.

Location: Joseph Henry Room Jadwin Hall

Stephanie Palmer: How behavioral and evolutionary constraints sculpt early visual processing

Mon, Feb 17, 2020, 12:00 pm

While efficient coding has been a successful organizational principle in visual neuroscience, to make a more general theory behavioral,...

Location: Joseph Henry Room Jadwin Hall

Information flow in bacterial communities

Fri, Feb 21, 2020, 9:30 am

Location: The Graduate Center, Room 4102. 365 Fifth Avenue, 365 Fifth Avenue, New York

Andrew York: TBD

Mon, Feb 24, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Andreas Gahlman: TBD

Mon, Mar 9, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Andreas Gahlmann: TBD

Mon, Mar 9, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

CPBF undergraduate outreach at CUNY

Fri, Mar 13, 2020, 1:30 pm to 4:00 pm
Location: Science Center (4102) at The Graduate Center. 365 Fifth Avenue, New York

Allan Drummond: TBD

Mon, Mar 16, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Na Ji: Imaging the brain at high spatiotemporal resolution

Mon, Mar 23, 2020, 12:00 pm

To understand computation in the brain, one needs to understand the input-output relationships for neural circuits and the anatomical and...

Location: Joseph Henry Room Jadwin Hall

Stefano Allesina: TBD

Mon, Mar 30, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall