Dmitry Rinberg: Cracking the olfactory code using behavior

Mon, Jan 27, 2020, 12:00 pm
Location: 
Joseph Henry Room Jadwin Hall
Speaker(s): 
Sponsor(s): 
CPBF an NSF PFC

Two of the most fundamental questions of sensory neuroscience are: 1) how is stimulus information represented by neuronal activity? and 2) what features of this activity are read out to guide behavior? The first question has been the subject of a large body of work across different sensory modalities. The second question remains a significant challenge, since one needs to establish a causal link between neuronal activity and behavior.

In olfaction, it has been proposed that information about odors is encoded in spatial distribution of receptor activation and the next level mitral/tufted cells, as well as in their relative timing and synchrony. However, the role of different features of neural activity in guiding behavior remains unknown. Using mouse olfaction as a model system, we developed both technological and conceptual approaches to study sensory coding by perturbing neural activity at different levels of information processing during sensory driven behavioral tasks. We developed methods for both one-photon spatiotemporal pattern stimulation using digital mirror devices at the glomerulus level in the olfactory bulb, and two-photon holographic pattern stimulation deeper in the brain, at the level of mitral/tufted cells. Using these techniques, we performed quantitative behavioral experiments to, first, measure psychophysical limits of the readability of different features of the neural code, and, second, to quantify their behavioral relevance. Based on these results, we built a detailed mathematical model of the behavioral relevance of the different features of spatiotemporal neural activity. Our approach can be potentially generalized to other sensory systems.

Dmitry Rinberg: Cracking the olfactory code using behavior

Mon, Jan 27, 2020, 12:00 pm

Two of the most fundamental questions of sensory neuroscience are: 1) how is stimulus information represented by neuronal activity?

Location: Joseph Henry Room Jadwin Hall

Sven van Teeffelen: Control of cell volume in rod-shaped bacteria

Mon, Feb 3, 2020, 12:00 pm

Bacteria exhibit a high degree of intracellular macromolecular crowding.

Location: Joseph Henry Room Jadwin Hall

Elizabeth Jerison: Dynamics of adaptive immunity in zebrafish

Mon, Feb 10, 2020, 12:00 pm

The immune responses that defend us against pathogens are driven by stochastic processes amongst populations of cells.

Location: Joseph Henry Room Jadwin Hall

Stephanie Palmer: How behavioral and evolutionary constraints sculpt early visual processing

Mon, Feb 17, 2020, 12:00 pm

While efficient coding has been a successful organizational principle in visual neuroscience, to make a more general theory behavioral,...

Location: Joseph Henry Room Jadwin Hall

Information flow in bacterial communities

Fri, Feb 21, 2020, 9:30 am

Location: The Graduate Center, Room 4102. 365 Fifth Avenue, 365 Fifth Avenue, New York

Andrew York: TBD

Mon, Feb 24, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Andreas Gahlman: TBD

Mon, Mar 9, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Andreas Gahlmann: TBD

Mon, Mar 9, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

CPBF undergraduate outreach at CUNY

Fri, Mar 13, 2020, 1:30 pm to 4:00 pm
Location: Science Center (4102) at The Graduate Center. 365 Fifth Avenue, New York

Allan Drummond: TBD

Mon, Mar 16, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Na Ji: Imaging the brain at high spatiotemporal resolution

Mon, Mar 23, 2020, 12:00 pm

To understand computation in the brain, one needs to understand the input-output relationships for neural circuits and the anatomical and...

Location: Joseph Henry Room Jadwin Hall

Stefano Allesina: TBD

Mon, Mar 30, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall