Benny Chain: The T cell receptor repertoire in health and disease

Mon, Mar 25, 2019, 12:00 pm
Location: 
Joseph Henry Room Jadwin Hall
Speaker(s): 

The human adaptive immune system makes robust decisions which regulate quantitative and qualitative parameters of a complex physiological system, to prevent invasion and destruction of tissues by the enormous array of microorganisms which share our environment. Remarkably, these decisions are made by a distributed system made up of moving parts (e.g. T lymphocytes) and whose key recognition components (T cell antigen receptors) are assembled by a stochastic process. In this seminar, I will review some basic properties of the repertoire of T cell antigen receptors, and then outline the basic features of an open-source quantitative, robust and economical experimental and computational pipeline which allows us to capture the repertoire of T cell receptors in samples of tissues or blood. We have used this method to describe basic features of the T cell repertoire of naïve and memory T cells in a group of healthy human volunteers, and to compare this with the T cell repertoire within tumors from a cohort of patients with primary non-small cell lung cancer. We observe that the T cell compartment maintains significant levels of diversity even in the face of long-term chronic clonal expansion. We hypothesise that the enormous diversity of the T cell receptor repertoire is a key feature ensuring that the adaptive immune response is made up of many co-operating T cell clones, which may confer both robustness and flexibility.

Bill Bialek & Josh Shaevitz: state of the Center

Mon, Sep 16, 2019, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Zaida Luthey-Schulten: TBD

Mon, Sep 23, 2019, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Andrew Mugler: TBD

Mon, Sep 30, 2019, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

David Van Valen: TBD

Mon, Oct 7, 2019, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

John Marko: TBD

Mon, Oct 14, 2019, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Aleksandra Walczak: TBD

Mon, Oct 21, 2019, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Ashley Carter: DNA Folding in Sperm

Mon, Nov 4, 2019, 12:00 pm

In sperm, DNA is tightly compacted to create a small, hydrodynamic sperm head.

Paul Francois: TBD

Mon, Nov 11, 2019, 12:00 pm

Marija Zanic: TBD

Mon, Nov 18, 2019, 12:00 pm

Damon Clark: TBD

Mon, Dec 2, 2019, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Hana El-Samad: TBD

Mon, Dec 9, 2019, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Dmitry Rinberg: TBD

Mon, Jan 27, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall