Ashley Carter: DNA Folding in Sperm

Mon, Nov 4, 2019, 12:00 pm
Location: 
Joseph Henry Room Jadwin Hall
Speaker(s): 
Sponsor(s): 
CPBF an NSF PFC

In sperm, DNA is tightly compacted to create a small, hydrodynamic sperm head. This dramatic reorganization of the nucleus is carried out by protamine proteins that fold the DNA into loops and toroids. Here, I'll talk about the pathway and physical mechanism of that DNA folding.  We will look at images of single molecules of DNA with bound protamine using an atomic force microscope (AFM) and also real-time folding dynamics using an optical trapping assay. We expected DNA folding in sperm to be similar to DNA folding in bacteria with DNA looping happening in a single step. We also thought that forming a DNA toroid would follow the “one ring” model where a single ring or loop of DNA acts as the nucleation event for the toroid. But, our data showed that DNA folding in sperm is completely different than our expectations. We are now using our findings to fold and assemble DNA origami nanostructures.

Aleksandra Walczak: Response in immune repertories

Mon, Oct 21, 2019, 12:00 pm

The immune repertoire responds to a wide variety of pathogenic threats. Immune repertoire sequencing experiments give us insight into the...

Location: Joseph Henry Room Jadwin Hall

Ashley Carter: DNA Folding in Sperm

Mon, Nov 4, 2019, 12:00 pm

In sperm, DNA is tightly compacted to create a small, hydrodynamic sperm head.

Location: Joseph Henry Room Jadwin Hall

Paul Francois: TBD

Mon, Nov 11, 2019, 12:00 pm

Searching for simpler models

Fri, Nov 15, 2019, 9:30 am

Neural network pruning and the lottery ticket hypothesis
Jonathan Frankle, Massachusetts Institute of Technology

Location: The Graduate Center, Skylight Room, 9100. 365 Fifth Avenue, between 34th and 35th Streets, in Manhattan

Marija Zanic: Dynamic Architecture of the Microtubule Cytoskeleton

Mon, Nov 18, 2019, 12:00 pm

Microtubules are active biological polymers known to stochastically switch between phases of growth and shrinkage, a behavior termed ‘dynamic...

Melike Lakadamyali: Super-resolution imaging of cellular organization

Mon, Nov 25, 2019, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Damon Clark: TBD

Mon, Dec 2, 2019, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Adaptation

Fri, Dec 6, 2019, 9:30 am

Adaptation and Bayesian forecasting in biological systems
Thierry Mora, École Normale Supérieure and Princeton University...

Location: The Graduate Center, Segal Theater. 365 Fifth Avenue, between 34th and 35th Streets, in Manhattan

Hana El-Samad: TBD

Mon, Dec 9, 2019, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Navish Wadhwa: TBD

Mon, Dec 16, 2019, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Dmitry Rinberg: TBD

Mon, Jan 27, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall

Sven van Taeffelen: TBD

Mon, Feb 3, 2020, 12:00 pm
Location: Joseph Henry Room Jadwin Hall