Allan Drummond: Rethinking the cellular response to heat shock, from biophysics to physiology

Cells across the tree of life respond to a sudden, nonlethal rise in temperature--heat shock--in similar ways. Following heat shock, proteins and mRNAs form clumps, certain genes turn on, and protein synthesis and cell growth sharply decline. The standard interpretation of these long-studied phenomena has held that thermal energy causes proteins to misfold, forming toxic aggregates that require cleanup by the induced chaperone proteins. Substantial challenges to this misfolding-catastrophe interpretation have remained. A fundamentally different picture emerges from recent work: aggregation instead reflects evolved, adaptive biomolecular condensation processes integral to the sensation of and adaptation to temperature, and chaperones regulate these condensed states. I will discuss our ongoing molecular and cell-biological studies which have led to this alternative perspective in which temperature acts as a signal, rather than a proteotoxic stress.

 

Allan Drummond: Rethinking the cellular response to heat shock, from biophysics to physiology

Mon, Oct 26, 2020, 12:15 pm

Cells across the tree of life respond to a sudden, nonlethal rise in temperature--heat shock--in similar ways.

Location: Zoom

Dialogue on droplets with Shana Elbaum-Garfinkle and Stephanie Weber

Thu, Nov 5, 2020, 7:30 pm

Dialogue on droplets:

Shana Elbaum-Garfinkle, ASRC, The CUNY Graduate Center

Stephanie Weber, McGill University...

Location: Zoom

Chromosomes, condensates, and transcriptional control

Fri, Nov 6, 2020, 10:00 am

All cells must control the reading out (“transcription”) of information encoded in their DNA.  

Location: Zoom

Seppe Kuehn: TBD

Mon, Nov 9, 2020, 12:15 pm
Location: Zoom

Kranthi Kiran Mandadapu: TBD

Mon, Nov 23, 2020, 12:15 pm
Location: Zoom

How children learn language with Jenny Saffran

Thu, Dec 3, 2020, 7:30 pm

How children learn language:

Jenny Saffran, University of Wisconsin 

Location: Zoom

Language, learning, and networks

Fri, Dec 4, 2020, 10:00 am

We are in the midst of a revolution driven by models for learning in neural networks.

Location: Zoom